Neurodegenerative Disease

Prostaglandins, Leukotrienes and Essential Fatty Acids

Cytokines / Inflammation / Diet / Brain / Drugs / Humans / Animals / Astrocyte / Glial Cell / Clinical Sciences / Immune system / Fatty Acid / Neurodegenerative Disease / Biochemistry and cell biology / Innate Immune System / Humans / Animals / Astrocyte / Glial Cell / Clinical Sciences / Immune system / Fatty Acid / Neurodegenerative Disease / Biochemistry and cell biology / Innate Immune System

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Gene expression profiling in vLINCL CLN6-deficient fibroblasts: Insights into pathobiology

Membrane Proteins / Extracellular Matrix / Molecular Mechanics / Biological Sciences / Humans / Cell Mechanics / Cholesterol / Cell Death / Physical sciences / Statistical Significance / Signal Transduction Pathway Models / Clinical Sciences / Lipid Raft / Neurodegenerative Disease / Cdna Microarray / Human Fibroblasts / Structure Function / Biochemistry and cell biology / Gene expression profiling / Inflammatory response / Cell Mechanics / Cholesterol / Cell Death / Physical sciences / Statistical Significance / Signal Transduction Pathway Models / Clinical Sciences / Lipid Raft / Neurodegenerative Disease / Cdna Microarray / Human Fibroblasts / Structure Function / Biochemistry and cell biology / Gene expression profiling / Inflammatory response

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HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model

Enzyme Inhibitors / Gene expression / Multidisciplinary / Cerebellum / Mice / Animals / Histone Modification / PLoS one / Chromatin / Introns / Histones / Mouse Model / Microarray Analysis / Myocardium / Chromatin Immunoprecipitation / Western blot / Acetylation / Neurodegenerative Disease / Histone deacetylase inhibitor / Nervous System / Autosomal Recessive / Acute Toxicity / Cardiac Disease / Friedreich Ataxia / Gene expression profiling / Histone deacetylase inhibitors / Iron binding proteins / Animals / Histone Modification / PLoS one / Chromatin / Introns / Histones / Mouse Model / Microarray Analysis / Myocardium / Chromatin Immunoprecipitation / Western blot / Acetylation / Neurodegenerative Disease / Histone deacetylase inhibitor / Nervous System / Autosomal Recessive / Acute Toxicity / Cardiac Disease / Friedreich Ataxia / Gene expression profiling / Histone deacetylase inhibitors / Iron binding proteins

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TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer’s disease and frontotemporal lobar degeneration

Dementia / Brain / Humans / Female / Male / Immunoprecipitation / Clinical Sciences / Aged / Middle Aged / Adult / ACTA / Frontotemporal Dementia / Neurodegenerative Disease / Biological markers / Indexation / Alzheimer Disease / DNA binding proteins / Laboratory Tests / Neurosciences / Enzyme Linked Immunosorbent Assay / Immunoprecipitation / Clinical Sciences / Aged / Middle Aged / Adult / ACTA / Frontotemporal Dementia / Neurodegenerative Disease / Biological markers / Indexation / Alzheimer Disease / DNA binding proteins / Laboratory Tests / Neurosciences / Enzyme Linked Immunosorbent Assay

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Gene expression profiling in vLINCL CLN6-deficient fibroblasts: Insights into pathobiology

Membrane Proteins / Extracellular Matrix / Molecular Mechanics / Biological Sciences / Inflammatory Immune Response / Humans / Cell Mechanics / Cholesterol / Cell Death / Physical sciences / Statistical Significance / Signal Transduction Pathway Models / Clinical Sciences / Lipid Raft / Neurodegenerative Disease / Cdna Microarray / Human Fibroblasts / Structure Function / Biochemistry and cell biology / Gene expression profiling / Humans / Cell Mechanics / Cholesterol / Cell Death / Physical sciences / Statistical Significance / Signal Transduction Pathway Models / Clinical Sciences / Lipid Raft / Neurodegenerative Disease / Cdna Microarray / Human Fibroblasts / Structure Function / Biochemistry and cell biology / Gene expression profiling

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Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities

Electron Microscopy / Multiple sclerosis / Immunohistochemistry / Western blotting / Brain / Humans / Mice / Animals / Laboratory / Enzyme / Clinical Sciences / Neurodegenerative Disease / Arginine / Citrulline / Demyelinating disease / Glycosyl Hydrolases / Myelin Sheath / Humans / Mice / Animals / Laboratory / Enzyme / Clinical Sciences / Neurodegenerative Disease / Arginine / Citrulline / Demyelinating disease / Glycosyl Hydrolases / Myelin Sheath

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Determinación de algunos atributos de calidad de la variedad Fuji y sus mutantes al momento de cosecha

vitamin C / Fruit and vegetables / Ciência e Tecnologia / Neurodegenerative Disease / Ciencia y Tecnología / Food Sciences / Skin Color / Indexation / Ciência e Tecnologia de Alimentos / Fruit Quality / Total Soluble Solids / Food Sciences / Skin Color / Indexation / Ciência e Tecnologia de Alimentos / Fruit Quality / Total Soluble Solids

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Determinación de algunos atributos de calidad de la variedad Fuji y sus mutantes al momento de cosecha Determination of some quality parameters of the Fuji cultivar and their mutants at harvest

vitamin C / Fruit and vegetables / Ciência e Tecnologia / Neurodegenerative Disease / Ciencia y Tecnología / Food Sciences / Skin Color / Indexation / Ciência e Tecnologia de Alimentos / Fruit Quality / Total Soluble Solids / Food Sciences / Skin Color / Indexation / Ciência e Tecnologia de Alimentos / Fruit Quality / Total Soluble Solids

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Knockdown of Cytosolic Glutaredoxin 1 Leads to Loss of Mitochondrial Membrane Potential: Implication in Neurodegenerative Diseases

Immunohistochemistry / Mitochondria / Multidisciplinary / Neurodegenerative Diseases / Antioxidants / Humans / Reactive Oxygen Species / Polymerase Chain Reaction / Animal Model / PLoS one / Mitochondrial dysfunction / Neurodegenerative Disease / Matrix Metalloproteinases / Mitochondrial Permeability Transition Pore / Base Sequence / Mitochondrial Membrane Potential / Outer Membrane Protein / Nucleotides / Down-Regulation / Humans / Reactive Oxygen Species / Polymerase Chain Reaction / Animal Model / PLoS one / Mitochondrial dysfunction / Neurodegenerative Disease / Matrix Metalloproteinases / Mitochondrial Permeability Transition Pore / Base Sequence / Mitochondrial Membrane Potential / Outer Membrane Protein / Nucleotides / Down-Regulation

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Transcriptional regulation of iNOS and COX-2 by a novel compound from Curcuma comosa in lipopolysaccharide-induced microglial activation

Neuroscience / Psychology / Cognitive Science / Transcription Regulation / Western blotting / Lipopolysaccharide / Cell line / Animals / Microglia / Anti-inflammatory agents / Lipopolysaccharides / Plant extracts / Rats / Neurodegenerative Disease / Anti Inflammatory Activity / Curcuma / Neurosciences / Lipopolysaccharide / Cell line / Animals / Microglia / Anti-inflammatory agents / Lipopolysaccharides / Plant extracts / Rats / Neurodegenerative Disease / Anti Inflammatory Activity / Curcuma / Neurosciences

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Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase

Protein Folding / Multidisciplinary / Macromolecular X-Ray Crystallography / Amyotrophic Lateral Sclerosis / Free Radical / Humans / Differential scanning calorimetry / Escherichia coli / Animals / Fishes / Superoxide Dismutase / Enzyme / Cattle / Antioxidant enzyme / Molecular cloning / Active site / Protein Secondary Structure Prediction / Neurodegenerative Disease / Amino Acid Sequence / Recombinant Proteins / Dimerization / Disulfide bond / Photobacterium / Humans / Differential scanning calorimetry / Escherichia coli / Animals / Fishes / Superoxide Dismutase / Enzyme / Cattle / Antioxidant enzyme / Molecular cloning / Active site / Protein Secondary Structure Prediction / Neurodegenerative Disease / Amino Acid Sequence / Recombinant Proteins / Dimerization / Disulfide bond / Photobacterium

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Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities

Electron Microscopy / Multiple sclerosis / Immunohistochemistry / Western blotting / Brain / Humans / Mice / Animals / Laboratory / Enzyme / Clinical Sciences / Neurodegenerative Disease / Arginine / Citrulline / Demyelinating disease / Glycosyl Hydrolases / Myelin Sheath / Humans / Mice / Animals / Laboratory / Enzyme / Clinical Sciences / Neurodegenerative Disease / Arginine / Citrulline / Demyelinating disease / Glycosyl Hydrolases / Myelin Sheath

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HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer\'s disease-linked exon skipping of presenilin-2 pre-mRNA

Genetics / Humans / Cell Death / Endoplasmic Reticulum / ER stress / Alternative splicing / Genes / RNA-binding proteins / Presenilin-2 / Neurodegenerative Disease / Alternative Splicing / Base Sequence / Alzheimer Disease / Binding Site / Biochemistry and cell biology / Alternative splicing / Genes / RNA-binding proteins / Presenilin-2 / Neurodegenerative Disease / Alternative Splicing / Base Sequence / Alzheimer Disease / Binding Site / Biochemistry and cell biology

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Retinal Muller glia secrete apolipoproteins E and J which are efficiently assembled into lipoprotein particles

Cognitive Science / Molecular chaperones / Optic Nerve / Animals / Male / Retina / Glial Cell / Liposomes / Glycoproteins / Lipoprotein(a) / Lipoproteins / Retinal Ganglion Cells / Neurodegenerative Disease / Nervous System / Rabbits / Neurosciences / Clusterin / Retina / Glial Cell / Liposomes / Glycoproteins / Lipoprotein(a) / Lipoproteins / Retinal Ganglion Cells / Neurodegenerative Disease / Nervous System / Rabbits / Neurosciences / Clusterin

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Mitochondrial DNA integrity is not dependent on DNA polymerase-β activity

Electron Microscopy / DNA repair / Single molecule / Mitochondrial DNA / Humans / Mutation / Mice / Animals / DNA sequence design / Enzyme / Density gradient / Neurodegenerative Disease / Base Excision Repair / Functional Testing / DNA Polymerase / Biochemistry and cell biology / Mutation / Mice / Animals / DNA sequence design / Enzyme / Density gradient / Neurodegenerative Disease / Base Excision Repair / Functional Testing / DNA Polymerase / Biochemistry and cell biology

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Emotion comprehension in the temporal variant of frontotemporal dementia

Dementia / Cognition / Magnetic Resonance Imaging / Facial expression / Emotions / Temporal Lobe / Brain / Humans / Female / Male / Frontal Cortex / Temporal Cortex / Mini Mental State Examination / Aged / Middle Aged / Analysis of Variance / Frontotemporal Dementia / Neurodegenerative Disease / Frontal Lobe / Region of Interest / Behavioural Problems / Temporal Lobe / Brain / Humans / Female / Male / Frontal Cortex / Temporal Cortex / Mini Mental State Examination / Aged / Middle Aged / Analysis of Variance / Frontotemporal Dementia / Neurodegenerative Disease / Frontal Lobe / Region of Interest / Behavioural Problems

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